AR7
Produktgrößen
5 mg
£168,00
10-5515-5MG
25 mg
£320,00
10-5515-25MG
Über dieses Produkt
- SKU:
- 10-5515
- CAS Number:
- 80306-38-3
- Weitere Details:
- Atypical retinoid which acts as an RARA Alpha antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway.1 Downstream signaling results in an increase of LAMP-2A expression.1 Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model.1 AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease modifying strategy in Parkinson's disease3. A targetome analysis of AR7-induced CMA in cancer cells has been performed.4
- Immunogen:
- Retinoid receptor and related|Transcription factor
- Molekulargewicht:
- 257.72
- Physischer Zustand:
- Solid
- Reinheit:
- 98%
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here