ML401
Produktgrößen
5 mg
£182,00
10-5280-5MG
25 mg
£339,00
10-5280-25MG
Über dieses Produkt
- SKU:
- 10-5280
- Zusätzliche Namen:
- CID73169083|SID 173333998
- CAS Number:
- 1597489-14-9
- Weitere Details:
- ML401 is a potent antagonist of GPR183 (IC50 = 1.03 nM), also known as EBI2 or Epstein-Barr virus-induced gene 2. ML401 inhibited 7A Alpha,25-dihydroxycholesterol-induced RS11846 cell chemotaxis, IC50=6 nM.1 GPR183 is a key chemotactic receptor guiding B cell localization to appropriate microenvironments for activation and differentiation.2 It also regulates the homeostasis, localization and immunological function of splenic dendritic cells.3 Oxysterols have been shown to be endogenous ligands for GPR183 with 7A Alpha,25-dihydroxycholesterol being the most potent (Kd=450 pM).4
- Immunogen:
- GPCR
- Molekulargewicht:
- 419.75
- Physischer Zustand:
- Solid
- Reinheit:
- >98%
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors