DBIC
Produktgrößen
5 mg
£173,00
10-5161-5MG
25 mg
£339,00
10-5161-25MG
Über dieses Produkt
- SKU:
- 10-5161
- CAS Number:
- 487026-67-5
- Weitere Details:
- Specifically inhibits S-nitrosylation of DNA methyltransferase 3B (DNMT3B) at low concentrations, IC50≤100 nM, without affecting its enzymatic activity. Treatment with DBIC prevents nitric oxide-induced conversion of human colonic adenoma to adenocarcinoma in vitro. Treatment with DBIC strongly attenuates tumor development in a mouse model of carcinogenesis triggered by inflammation-induced NO production. DNMT3B-mediated DNA methylation is regulated by S-nitrosylaton and DBIC represents a new useful tool for studying this system.1 A negative control compound, DBIC-neg2 (Cat # 10-5162) is also available.
- Immunogen:
- DNA|Methyltransferase|Nucleic acid methylation
- Molekulargewicht:
- 296.29
- Physischer Zustand:
- Solid
- Reinheit:
- >98%
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here