ML792
Produktgrößen
5 mg
£192,00
10-4985-5MG
25 mg
£387,00
10-4985-25MG
Über dieses Produkt
- SKU:
- 10-4985
- CAS Number:
- 1644342-14-2
- Weitere Details:
- ML792 is a potent (IC50's = 3 nM SUMO1; 11 nM SUMO2) and selective( IC50 = 32 uM for NEDD8-activating enzyme (NAE)) mechanism-based inhibitor of SUMO-activating enzyme (SAE).1 Treatment of multiple cancer cell lines led to failure of mitotic progression and induction of endoreduplication with MYC-amplified cell lines showing higher sensitivity. ML792 inhibited B-cell growth and promoted cell death in Epstein-Barr virus (EBV)-positive B cells and nasopharyngeal carcinoma cells. It also modulated Latent Membrane Protein-1-induced cell migration and cell adhesion suggesting therapeutic potential in treating EBV-associated malignancies.2
- Immunogen:
- Ubiquitin ligase
- Molekulargewicht:
- 551.42
- Physischer Zustand:
- Solid
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors