Pexidartinib
Produktgrößen
5 mg
£144,00
10-4829-5MG
25 mg
£195,00
10-4829-25MG
Über dieses Produkt
- SKU:
- 10-4829
- Zusätzliche Namen:
- PLX3397
- CAS Number:
- 1029044-16-3
- Weitere Details:
- Pexidartinib (1029044-16-3) is a potent and selective dual inhibitor of CSF1R (IC50 = 20nM) and c-KIT (IC50 = 10nM).1 Inhibition of CSF1R with Pexidartinib resulted in a reprogrammed immune microenvironment that fosters antitumor immunity in a CD8+ T-cell-dependent manner in a breast cancer model.1 CSF1R recruits tumor-infiltrating myeloid cell that suppress tumor immunity - Pexidartinib increased the efficacy of adoptive cell immunotherapy (ACT) in a mouse melanoma model by inhibiting the intratumoral accumulation of immunosuppressive macrophages.2,3 It has also been shown to increase the efficacy of anti-PD-14,5 and DC immunotherapy 6.
- Immunogen:
- Kinase
- Molekulargewicht:
- 417.81
- Physischer Zustand:
- Solid
- Reinheit:
- 98%
- Aufreinigung:
- HPLC Purified
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here