ML365
Produktgrößen
5 mg
£168,00
10-4658-5MG
25 mg
£267,00
10-4658-25MG
Über dieses Produkt
- SKU:
- 10-4658
- CAS Number:
- 947914-18-3
- Weitere Details:
- ML365 is a potent (IC50 = 16 nM) and selective (62-fold selective over TASK-3) blocker of the two-pore domain potassium channel K2P3.1 (TASK-1) .1 It also less potently (IC50 = 4.07 uM) blocks the K2P6.1 (TWIK-2) channel resulting in blocking the ATP-induced NLRP3 inflammasome.2 ML365 improved the efficacy of Levetiracetam in chronically epileptic rats.3 It suppressed the release of TNF-A Alpha, IL-6, and IL-1B Beta in an LPS-induced inflammatory model via regulation of NF-kB signaling.4
- Immunogen:
- Inflammasome|Ion channel
- Molekulargewicht:
- 360.41
- Physischer Zustand:
- Solid
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here