P505-15
Produktgrößen
5 mg
£173,00
10-4650-5MG
25 mg
£291,00
10-4650-25MG
Über dieses Produkt
- SKU:
- 10-4650
- Zusätzliche Namen:
- BIIB-057|PRT062607
- CAS Number:
- 1370261-97-4
- Weitere Details:
- P505-15 is a highly selective and potent (IC50 = 1-2 nM) inhibitor of spleen tyrosine kinase (Syk).1 It potently inhibited B cell antigen receptor-mediated B cell signaling/activation and basophil degranulation. It displayed anti-inflammatory activity in rodent models of rheumatoid arthritis. P505-15 displayed efficacy in vitro and in vivo in non-Hodgkin lymphoma and chronic lymphocytic leukemia models.2,3 It protected against toxin-induced hepatic fibrosis, associated hepatocellular injury, and hepatocarcinogenesis.4 P505-15 was also found to inhibit PINK1 (IC50 = 0.5-3 uM) in HeLa cells and dopaminergic neurons.5
- Immunogen:
- Kinase
- Molekulargewicht:
- 429.91
- Physischer Zustand:
- Solid
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors