FPS-ZM1
Produktgrößen
10 mg
£153,00
10-4616-10MG
50 mg
£267,00
10-4616-50MG
Über dieses Produkt
- SKU:
- 10-4616
- CAS Number:
- 945714-67-0
- Weitere Details:
- FPS-ZM1 is a high-affinity Receptor for Advanced Glycation End products (RAGE) inhibitor (IC50 = 0.6 uM). It is able to lower levels of AB Beta via binding to the V domain of RAGE and can block multiple mechanisms of AB Beta40- and AB Beta42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivo.1,2 Can cross the BBB. In a rat model of intracerebral hemorrhage, FPS-ZM1 was able to attenuate blood-brain barrier and white matter fiber damage.3 FPS-ZM1 inhibition of RAGE was able to ameliorate inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1(HMGB1) signaling.4 FPS-ZM1 has also been shown to impair breast cancer cell invasion and metastasis.5
- Molekulargewicht:
- 327.85
- Physischer Zustand:
- Solid
- Reinheit:
- 98%
- Aufreinigung:
- HPLC Purified
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here