3PO
Produktgrößen
10 mg
£144,00
10-4609-10MG
50 mg
£214,00
10-4609-50MG
Über dieses Produkt
- SKU:
- 10-4609
- CAS Number:
- 18550-98-6
- Weitere Details:
- 3PO is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3). PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic rate (Warburg Effect) of these cells. 3PO inhibits PFKFB3 (IC50 = 1.4 - 24 uM for various cancer cell lines), suppresses glucose uptake, and lowers intracellular concentrations of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.1 Inhibition of cancer cell metabolism via blocking the action of PFKFB3 has been studied in various models.2-4 Inhibition of PFKFB3 has been shown to induce autophagy as a survival mechanism in cancer cells.5 3PO has also been used to reduce pathological angiogenesis.6
- Immunogen:
- Energy production|PFKFB3 (6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3)
- Molekulargewicht:
- 210.23
- Physischer Zustand:
- Solid
- Reinheit:
- 99%
- Aufreinigung:
- HPLC Purified
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors