TH588
Produktgrößen
5 mg
£163,00
10-4602-5MG
25 mg
£243,00
10-4602-25MG
Über dieses Produkt
- SKU:
- 10-4602
- CAS Number:
- 1609960-31-7
- Weitere Details:
- TH588 is a first-in-class nudix hydrolase family inhibitor.1 MTH1/NUDT1 is a family member that "sanitizes" oxidized deoxynucleotide triphosphates (dNTP) preventing their incorporation into DNA and thus avoiding DNA damage and cell death. TH588 inhibits MTH1/NUDT1 (IC50 = 5 nM) leading to cell death in several cancer cell lines while not affecting normal cells. Active in vitro and in vivo. Recent evidence has raised doubts about the cancer-killing ability of MTH1 inhibition.2,3
- Molekulargewicht:
- 331.63
- Physischer Zustand:
- Solid
- Reinheit:
- 98%
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors