NHI-2
Produktgrößen
10 mg
£192,00
10-4555-10MG
50 mg
£431,00
10-4555-50MG
Über dieses Produkt
- SKU:
- 10-4555
- CAS Number:
- 1269802-97-2
- Weitere Details:
- NHI-2 is a selective inhibitor of Lactate Dehydrogenase A (LDHA) - IC50 in vitro = 14.7 uM (NADH), 10.5 uM (Pyruvate).1 NHI-2 has also shown cellular growth inhibitory effects against pancreatic cancer cells (PANC-1 cells IC50 = 22.2 uM normoxic and 4.0 uM hypoxic; LPC006 cells IC50 = 17.8 uM normoxic and 1.1 uM hypoxic) with increased efficacy in a cancer cells hypoxic environment.2 LDHA is a key enzyme involved in the Warburg effect and a cancer cells ability to survive in a hypoxic environment.
- Immunogen:
- Dehydrogenase (GAPDH, GPDH, IMPDH, PHGDH, LDH, DHODH, ALDH, GDH, IDH, UGDH, DPD, DHPDH, KGDH, PDH, and MDH)|Energy production
- Molekulargewicht:
- 335.28
- Physischer Zustand:
- Solid
- Reinheit:
- 98%
- Aufreinigung:
- HPLC Purified
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here