7-Cl-O-Nec1
Produktgrößen
5 mg
£158,00
10-4544-5MG
10 mM (in 1 ml DMSO)
£158,00
10-4544-10MM(IN1MLDMSO)
25 mg
£248,00
10-4544-25MG
Über dieses Produkt
- SKU:
- 10-4544
- Zusätzliche Namen:
- Nec-1s|Necrostatin1-S
- CAS Number:
- 852391-15-2
- Weitere Details:
- Necrostatin-1 analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec-1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4 7-Cl-O-Nec-1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50 = 210 nM vs. EC50 = 490 nM), no non-specific cytotoxicity at high concentrations (100 uM) and reasonable pharmacokinetic characteristics when used in mice.2 7-Cl-O-Nec-1 is recommended for cellular and in vivo use over Necrostatin-1.5
- Immunogen:
- Kinase
- Molekulargewicht:
- 277.71
- Physischer Zustand:
- Solid
- Reinheit:
- 98%
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here