Crisdesalazine
Produktgrößen
5 mg
£163,00
10-4416-5MG
25 mg
£354,00
10-4416-25MG
Über dieses Produkt
- SKU:
- 10-4416
- Zusätzliche Namen:
- AAD-2004
- CAS Number:
- 927685-43-6
- Weitere Details:
- Crisdesalazine is a potent inhibitor of microsomal prostaglandin E2 synthase-1 (IC50 = 230 nM).1 It also acted as a potent spin-trapping molecule and completely removed free radical at 50 nM. Crisdesalazine displayed efficacy in mouse models of ALS1 and Alzheimer's disease2. In a mouse model of spinal cord injury, it inhibited proliferation of astrocytes via hydrogen peroxide inhibition and promoted nerve regeneration.3 It also significantly alleviated clinical symptoms in a mouse model of multiple sclerosis by promoting the M1 to M2 phase transition in macrophages.4 Crisdesalazine in combination with cisplatin restored CD8+ T cell function and significantly improved efficacy compared to cisplatin monotherapy in an ovarian cancer model.5
- Immunogen:
- GPCR
- Molekulargewicht:
- 325.29
- Physischer Zustand:
- Solid
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors