ARN25499
Produktgrößen
5 mg
£173,00
10-4412-5MG
25 mg
£315,00
10-4412-25MG
Über dieses Produkt
- SKU:
- 10-4412
- Weitere Details:
- ARN25499 is a novel Cdc42 GTPase interaction inhibitor. It inhibits the interaction between Cdc42 and its downstream effectors (i.e PAK) instead of the Cdc42-GEF interaction. ARN25499 displayed activity against four melanoma cancer cell lines (IC50s: SKM28 13.5 uM, SKMeI3 8.1 uM, WM3248 12.8 uM, A375 9.7 uM) and one colon cancer line (IC50 = 11.2 uM SW480). It also displayed good pharmacokinetics in mice. ARN25499 also showed in vivo efficacy in melanoma PDX tumors in NSG mice at 10mg/kg.
- Immunogen:
- GTPase
- Molekulargewicht:
- 390.49
- Physischer Zustand:
- Solid
- Reinheit:
- 99%
- Aufreinigung:
- HPLC Purified
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors