Y-320
Produktgrößen
5 mg
£149,00
10-4276-5MG
25 mg
£219,00
10-4276-25MG
Über dieses Produkt
- SKU:
- 10-4276
- CAS Number:
- 288250-47-5
- Weitere Details:
- Y-320 is an inhibitor of IL-17 production (IC50 = 20 - 60 nM in CD4 T cells).1 It significantly inhibited the development and progression of arthritis and joint destruction in collagen-induced arthritis models. Y-320 acted synergistically with other chemotherapeutic agents to overcome multidrug resistance.2 It also enhances premature termination codon (PTC) readthrough resulting in increased protein levels and protein synthesis.3 Y-320 also acts as a potent oral sialylation inhibitor (IC50 = 200 nM in PDAC cells).4 It suppressed A Alpha-2,3/2,6-sialylation inhibiting PDAC tumor growth and remodeling the tumor microenvironment. Y-320 acted synergistically with anti-PD-1 therapy to overcome immune checkpoint blockade resistance.
- Molekulargewicht:
- 505.02
- Physischer Zustand:
- Solid
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors