PK11007
Produktgrößen
5 mg
£173,00
10-4176-5MG
25 mg
£281,00
10-4176-25MG
Über dieses Produkt
- SKU:
- 10-4176
- CAS Number:
- 874146-69-7
- Weitere Details:
- PK11007 reactivates mutant p53 via selective alkylation of two cysteine residues without compromising DNA-binding ability.1 p53 target genes p21 and PUMA were activated by treatment with PK11007. Mutant p53-containing cancer cells were more sensitive to PK11007 than wild-type with mutant cells showing greatly reduced viability. It also generated high levels of reactive oxygen species and induced ER stress in a p53-independent (and dependent on glutathione depletion) manner that resulted in cell death. PK11007 inhibited cellular proliferation, induced apoptosis, and blocked cell migration in a panel of 17 breast cancer lines including triple-negative breast cancer (IC50s: 2.3 to 42.2 uM).2
- Immunogen:
- Transcription factor
- Molekulargewicht:
- 427.85
- Physischer Zustand:
- Solid
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules