RU.521
Produktgrößen
5 mg
£192,00
10-4140-5MG
25 mg
£363,00
10-4140-25MG
Über dieses Produkt
- SKU:
- 10-4140
- CAS Number:
- 2262452-06-0
- Weitere Details:
- Inhibitor of cyclic GMP-AMP synthase (cGAS), an important innate immune system sensor of foreign cytoplasmic double-stranded DNA.1,2 IC50 = 0.70 uM in dsDNA-stimulated RAW macrophages1 and ~0.80 uM in wild type human THP-1 cells2. It is selective for cGAS with no targeting of IFNB1 protein, interferon receptors, or downstream signaling components of the JAK/STAT pathway. RU.521 was able to significantly increase cardiac output in a mouse model of sepsis.3 Active in both mouse and human cell lines.
- Immunogen:
- STING
- Molekulargewicht:
- 415.23
- Physischer Zustand:
- Solid
- Reinheit:
- 98%
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here