Imaradenant
Produktgrößen
5 mg
£168,00
10-4095-5MG
25 mg
£286,00
10-4095-25MG
Über dieses Produkt
- SKU:
- 10-4095
- Zusätzliche Namen:
- AZD4635
- CAS Number:
- 1321514-06-0
- Weitere Details:
- Imaradenant is a potent and selective A2AR antagonist (IC50 = 0.79 nM @ 0.1 uM adenosine).1 It restores T cell function and tumor antigen cross-presentation by CD103+ dendritic cells resulting in enhanced antitumor immunity. Imaradenant reduced tumor load in a murine model of multiple myeloma in combination with anti-CD73 therapy.2 It displayed efficacy in combination with PD-1 inhibitors against prostate cancer.3,4 AZD4635 increased the infiltration of cytotoxic T cells and decreased infiltration of immunosuppressive cells to increase the efficacy of PARP inhibitors in an ovarian cancer model.5
- Immunogen:
- GPCR
- Molekulargewicht:
- 315.74
- Physischer Zustand:
- Solid
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors