UNC7467
Produktgrößen
5 mg
£153,00
10-4080-5MG
25 mg
£272,00
10-4080-25MG
Über dieses Produkt
- SKU:
- 10-4080
- Zusätzliche Namen:
- 3-([1,1'-Biphenyl]-4-yl)benzo[c]isoxazole-5-carboxylic acid
- CAS Number:
- 2922283-43-8
- Weitere Details:
- Potent inhibitor of inositol hexakisphosphate kinase (IP6K) - the isoform IP3K1 regulates metabolism, promotes insulin secretion from B Beta cells, attenuates certain aspects of insulin signaling, and reduces whole-body energy expenditure by inhibiting adipocyte thermogenesis, thus making it an attractive target for treatment of obesity and obesity-induced metabolic dysfunction. It is selective for IP6K1 and 2 over IP6K3 (IC50s = 8.9 nM, 4.9 nM, and 1320 nM respectively). EC50 = 1.0 uM and 0.24 uM at 3hr and 18 hr respectively in intact HCT116 cells ([33]P-Pi efflux). Selective against a panel of 30 protein kinases and 5 CYP isoforms. UNC7467 improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake in diet-induced obese mice.
- Immunogen:
- Kinase
- Molekulargewicht:
- 315.33
- Physischer Zustand:
- Solid
- Reinheit:
- >98%
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here