URMC-099
Produktgrößen
5 mg
£153,00
10-4012-5MG
25 mg
£233,00
10-4012-25MG
Über dieses Produkt
- SKU:
- 10-4012
- CAS Number:
- 1229582-33-5
- Weitere Details:
- URMC-099 is a potent (IC50 = 14 nM), brain penetrant mixed-lineage kinase 3 inhibitor (MLK3). It also potently inhibits FLT3 (4 nM in vitro, but 560 nM in vivo), LRRK2 (11 nM), and ABL1 (3 nM).1 URMC-099 displayed neuroprotective effects in HIV-associated neurocognitive disorders2 and facilitated microglial amyloid- degradation and clearance in mouse models.3,4 URMC-099 increased CD8+ T cells in mice and increased the CD8+GZMB+ T cell population in blood mononuclear cells isolated from breast cancer patients.5
- Immunogen:
- Kinase|Lysosome
- Molekulargewicht:
- 421.54
- Physischer Zustand:
- Solid
- Reinheit:
- 98%
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors