Grapiprant
Produktgrößen
5 mg
£177,00
10-4006-5MG
25 mg
£291,00
10-4006-25MG
Über dieses Produkt
- SKU:
- 10-4006
- Zusätzliche Namen:
- ARY-007|CJ-023,423
- CAS Number:
- 415903-37-6
- Weitere Details:
- Grapiprant is a potent (Ki = 13 nM for human and 20 nM for rat) and selective prostaglandin EP4 receptor antagonist.1 It produces antihyperalgesic effects in animal models of pain, and has significant anti-inflammatory effects in a rat model of adjuvant-induced arthritis.2 EP4 receptors have been shown to be involved in PGE2 stimulation of Th1 differentiation and Th17 expansion revealing a potential role for PGE2 receptors in immunosuppression.3,4 Grapiprant/Pembrolizumab combination is in clinical trials for advanced or metastatic NSCLC adenocarcinoma.5
- Immunogen:
- GPCR
- Molekulargewicht:
- 491.61
- Physischer Zustand:
- Solid
- Reinheit:
- 98%
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors