Compound 147
Produktgrößen
10 mg
£144,00
10-3973-10MG
50 mg
£238,00
10-3973-50MG
Über dieses Produkt
- SKU:
- 10-3973
- Zusätzliche Namen:
- AA147
- CAS Number:
- 393121-74-9
- Weitere Details:
- Preferential activator of the ER stress sensing protein ATF6.1 It was able to selectively reduce secretion and extracellular aggregation of destabilized amyloidogenic variants of TTR and LC proteins. AA147-dependent ATF6 activation proceeds via metabolic activation to a reactive electrophile that selectively modifies ER proteins including multiple protein disulfide isomerases.2 AA147 suppressed pluripotency and promoted human stem cell differentiation toward a mesodermal lineage via ER expansion.3 It protected the heart against ischemia/reperfusion (I/R) injury in a mouse model of acute myocardial infarction in an ATF6-dependent manner.4 Brain, kidney, and liver tissue was also protected from I/R damage and impaired proteostasis. AA147 reduced infection of multiple strains of dengue and Zika viruses in an ATF6-independent manner.5 Protects against glutamate-induced cell death is a neuronal-derived cell culture model.6 See companion inhibitor 10-3974.
- Immunogen:
- ER/Golgi|Transcription factor|UPR (Unfolded protein response)
- Molekulargewicht:
- 255.32
- Physischer Zustand:
- Solid
- Reinheit:
- 98%
- Aufreinigung:
- HPLC Purified
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Sell Sheet 1:
- View Sell Sheet Here