RMC-7977
Produktgrößen
1 mg
£177,00
10-3954-1MG
5 mg
£334,00
10-3954-5MG
Über dieses Produkt
- SKU:
- 10-3954
- CAS Number:
- 2765082-12-8
- Weitere Details:
- RMC-7977 is broad spectrum inhibitor of both mutant and wild-type KRAS, NRAS, and HRAS variants.1 It binds with high affinity to cyclophilin A (KD = 195 nM) creating a binary complex that has high affinity for the active state of KRAS (KD = 85 nM for G12V). Active in in vivo xenograft models of NSCLC, CRC, and PDAC.1,2,3 RMC-7977 was able to overcome resistance to the KRASG12D selective inhibitor MRTX1133.1
- Immunogen:
- GTPase|Molecular glue
- Molekulargewicht:
- 865.11
- Physischer Zustand:
- Solid
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors