CPI-613
Produktgrößen
5 mg
£149,00
10-3519-5MG
25 mg
£243,00
10-3519-25MG
Über dieses Produkt
- SKU:
- 10-3519
- Zusätzliche Namen:
- Devimistat
- CAS Number:
- 95809-78-2
- Weitere Details:
- Lipoic acid analog which potently disrupts mitochondrial metabolism with selectivity for tumor cells in vitro and shows strong antitumor activity in vivo.1 Inhibits alpha-ketoglutarate dehydrogenase (KGDH) by a redox mechanisms selectively in tumor cells.2 Inhibits pyruvate dehydrogenase (PDH) as a mechanistically distinct, non-redox, effect.1,2 A novel anticancer agent with a mitochondria-targeted mode of action with non-genotoxic propertie.3. Has been used (along with PS48) to induce a Warburg-like metabolic state in fibroblasts.4 Combination treatment of CPI-613 and chloroquine inhibits the progression of clear cell sarcoma in a mouse model.5
- Immunogen:
- Dehydrogenase (GAPDH, GPDH, IMPDH, PHGDH, LDH, DHODH, ALDH, GDH, IDH, UGDH, DPD, DHPDH, KGDH, PDH, and MDH)|Glutathione
- Molekulargewicht:
- 388.59
- Physischer Zustand:
- Solid
- Reinheit:
- 98%
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Datenblatt des Herstellers:https://focusbiomolecules.com/cpi-613-kgdh-and-pdh-inhibitor/