B02
Produktgrößen
5 mg
£139,00
10-3425-5MG
25 mg
£195,00
10-3425-25MG
Über dieses Produkt
- SKU:
- 10-3425
- CAS Number:
- 1290541-46-6
- Weitere Details:
- RAD51 is a key protein involved in homologous recombination that plays a critical role in the repair of DNA double-strand breaks (DSB) and interstrand cross-links (ICL).1 B02 (1290541-46-6) was identified in a high-throughput screen using a DNA strand exchange assay and was found to specifically inhibit human RAD51 (IC50=27.4 uM) but not its E. coli homolog (RecA)1. It sensitizes multiple myeloma cells to doxorubicin2 and potentiates breast cancer cell killing by therapeutic agents in mouse models3. B02 induces a heat-shock protein mediated cellular response that positively regulates the conversion of rcDNA to cccDNA via the authentic intracellular amplification pathway in human hepatoma cells.4
- Immunogen:
- DNA
- Molekulargewicht:
- 339.4
- Physischer Zustand:
- Solid
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors