Pomalidomide
Produktgrößen
20 mg
£149,00
10-2768-20MG
100 mg
£195,00
10-2768-100MG
Über dieses Produkt
- SKU:
- 10-2768
- Zusätzliche Namen:
- 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide
- CAS Number:
- 19171-19-8
- Weitere Details:
- Thalidomide analog. Inhibits cereblon (CRBN) an E3 ubiquitin ligase, IC50 ~3 M for CRBN-DDB1 complex.1 Displays antiangiogenic and immunomodulatory activity in vivo potently inhibiting the production of TNF and IL-2.2 Promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.3 Conjugation with other ligands is a strategy to target proteins for in vivo proteasomal degradation via PROTACS.4,5
- Immunogen:
- Molecular glue|Ubiquitin ligase
- Molekulargewicht:
- 273.24
- Physischer Zustand:
- Solid
- Reinheit:
- 98%
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors