4u8C
Produktgrößen
5 mg
£131,00
10-1579-5MG
25 mg
£197,00
10-1579-25MG
Über dieses Produkt
- SKU:
- 10-1579
- CAS Number:
- 14003-96-4
- Weitere Details:
- Selective inhibitor of IRE1A Alpha ribonuclease (RNase) activity (IC50 = 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of IRE1A Alpha and inactivating both XBP1 splicing and IRE1A Alpha-mediated mRNA degradation but not IRE1 kinase activity1. Inhibits IRE1A Alpha in response to hypoxia or other ER stress-inducing agents but has no effect on proliferation or clonogenic survival of hypoxic cells2. Blocks production of IL-4, IL-5 and IL-13 production in T cells3. Prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in pancreatic B Beta-cells4.
- Immunogen:
- RNA|Transcription factor|UPR (Unfolded Protein Response)
- Molekulargewicht:
- 204.18
- Physischer Zustand:
- Solid
- Reinheit:
- 97%
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here