Dabrafenib
Produktgrößen
5 mg
£139,00
10-1569-5MG
25 mg
£214,00
10-1569-25MG
Über dieses Produkt
- SKU:
- 10-1569
- Zusätzliche Namen:
- GSK2118436
- CAS Number:
- 1195765-45-7
- Weitere Details:
- Dabrafenib is a selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50 = 3.2 and 5 nM, respectively).1 Has been in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors. Endoplasmic reticulum stress and autophagy are induced in melanoma cells after treatment with dabrafenib and protect cells from dabrafenib toxicity.2 Induces epithelial differentiation in BRAF-mutant colorectal cancer cells.3
- Immunogen:
- ER/Golgi|Kinase
- Molekulargewicht:
- 519.56
- Physischer Zustand:
- Solid
- Reinheit:
- 98%
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here