XIB4035
Produktgrößen
5 mg
£158,00
10-1486-5MG
25 mg
£281,00
10-1486-25MG
Über dieses Produkt
- SKU:
- 10-1486
- CAS Number:
- 10023-54-8
- Weitere Details:
- A novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor A Alpha-1 GFRA Alpha-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50=10.4 uM. Like GDNF, it induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells1. Recent studies indicate that it enhances GFRA Alpha family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3 GDNF agonists may be a new class of Parkinson's disease therapeutics.4
- Molekulargewicht:
- 750.45
- Physischer Zustand:
- Solid
- Reinheit:
- 98%
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- RT
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Sell Sheet 1:
- View Sell Sheet Here