6-Thioguanine
Produktgrößen
1 g
£129,00
10-1282-1G
100 mg
£129,00
10-1282-100MG
Über dieses Produkt
- SKU:
- 10-1282
- Zusätzliche Namen:
- 6-TG|NSC 752|NSC 76504
- CAS Number:
- 154-42-7
- Weitere Details:
- After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1).2 Incorporates into DNA and induces double strand breaks which destabilize DNA structure resulting in cytotoxicity.3 Selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in a xenograft model.4 Anticancer and immunosuppressive activity.
- Immunogen:
- DNA
- Molekulargewicht:
- 167.19
- Physischer Zustand:
- Solid
- Reinheit:
- 96%
- Aufreinigung:
- HPLC Purified
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here