Arecoline HBr
Produktgrößen
250 mg
£129,00
10-1016-250MG
1 g
£158,00
10-1016-1G
Über dieses Produkt
- SKU:
- 10-1016
- CAS Number:
- 300-08-3
- Weitere Details:
- Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is "hijacked" and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 uM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass.1 Agonist at muscarinic acetylcholine receptors M1 - M5 (EC50 in the range of 7-410 nM).2 May be effective in dementia.3
- Immunogen:
- Acetyltransferase|GPCR
- Molekulargewicht:
- 236.11
- Physischer Zustand:
- Solid
- Reinheit:
- 98%
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- RT
- Hersteller:
- Focus Biomolecules
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules