Anti-LARGE1 PE
Produktgrößen
0.025 mg
£159,00
1P-702-0.025MG
0.1 mg
£278,00
1P-702-0.1MG
Über dieses Produkt
- SKU:
- 1P-702
- Anwendung:
- Flow Cytometry
- CE/IVD:
- RUO
- translate.label.attr.clone:
- LARGE-02
- Konjugat:
- R-PE
- Konzentration:
- 0.1 mg/ml
- Weitere Details:
- LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.
- Immunogen:
- Recombinant fragment of human LARGE1 (amino acids 35-142)
- Isotyp:
- IgG2b
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Spezifität:
- The mouse monoclonal antibody LARGE-02 recognizes human LARGE1, a glycosyltransferase expressed mainly in the Golgi apparatus. Crossreactivity with LARGE2 was not determined.
- Lagerbedingungen:
- 2-8[o]C Do not freeze. Protect from light.
- Hersteller:
- Exbio
- Typ:
- Antibody
- FluoroFinder: