Anti-Rt CD8b PE
Produktgrößen
0.025 mg
£138,00
1P-656-0.025MG
0.1 mg
£235,00
1P-656-0.1MG
Über dieses Produkt
- SKU:
- 1P-656
- Anwendung:
- Flow Cytometry
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 341
- Konjugat:
- R-PE
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- The CD8b (CD8 beta) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages, mast cells, and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
- Immunogen:
- CD8 positive Wistar rat splenic T cell hybridomas
- Isotyp:
- IgG1, kappa
- Reaktivitäten:
- Rat
- Versandbedingungen:
- Blue Ice
- Spezifität:
- The mouse monoclonal antibody 341 (also known as 34.1) recognizes rat CD8b, the 32-34 kDa beta chain of the CD8 coreceptor (extracellular epitope), expressed on T cell subsets and some other cell types, such as macrophages.
- Lagerbedingungen:
- 2-8[o]C Do not freeze. Protect from light.
- Hersteller:
- Exbio
- Typ:
- Antibody
- FluoroFinder: