Anti-Hu CD16 Biotin
Produktgrößen
0.025 mg
£138,00
1B-646-0.025MG
0.1 mg
£235,00
1B-646-0.1MG
Über dieses Produkt
- SKU:
- 1B-646
- Anwendung:
- Flow Cytometry, IHC-Frozen, Immunoprecipitation
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 3G8
- Konjugat:
- Biotin
- Konzentration:
- 1 mg/ml
- Weitere Details:
- CD16 (FcgammaRIII) is a 50-65 kDa glycoprotein serving as a low affinity IgG receptor. Human FcgammaRIII is expressed in two forms - FcgammaRIII-A and -B. FcgammaRIII-A is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It is associated with FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FcgammaRIII-A is associated, moreover, with FcepsilonRI-beta subunit. Besides IgG, FcgammaRIII-A can be triggered also by oligomeric IgE. FcgammaRIII-B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype.
- Immunogen:
- Human neutrophils
- Isotyp:
- IgG1, kappa
- Reaktivitäten:
- Human, Non-human Primate
- Versandbedingungen:
- Blue Ice
- Spezifität:
- The mouse monoclonal antibody 3G8 recognizes an extracellular epitope of CD16, a low affinity receptor for aggregated IgG (FcgammaRIII antigen). CD16 exists in two different isoforms: CD16a (FcgammaRIIIA; 50-65 kDa; expressed on NK-cells, monocytes and macrophages) and CD16b (FcgammaRIIIB; 48 kDa; mainly expressed on neutrophils). Regarding CD16-158V/F polymorphism, the antibody 3G8 detects both 1
- Lagerbedingungen:
- 2-8[o]C Do not freeze.
- Hersteller:
- Exbio
- Typ:
- Antibody