Anti-Hu CD42b Purified Low Endotoxin
Produktgrößen
0.1 mg
£181,00
12-150-0.1MG
Über dieses Produkt
- SKU:
- 12-150
- Anwendung:
- ELISA, Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- AK2
- Konzentration:
- 1 mg/ml
- Weitere Details:
- CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.
- Immunogen:
- Human platelets
- Isotyp:
- IgG1
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Spezifität:
- The mouse monoclonal antibody AK2 recognizes an extracellular epitope of CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d.
- Lagerbedingungen:
- 2-8[o]C Do not freeze.
- Hersteller:
- Exbio
- Typ:
- Antibody