Anti-Ms CD8b Purified
Produktgrößen
0.025 mg
£111,00
11-779-0.025MG
0.1 mg
£181,00
11-779-0.1MG
Über dieses Produkt
- SKU:
- 11-779
- Anwendung:
- Flow Cytometry, IHC-Frozen, Immunoprecipitation
- CE/IVD:
- RUO
- translate.label.attr.clone:
- H35-17.2
- Konzentration:
- 1 mg/ml
- Weitere Details:
- The CD8b (CD8 beta) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages, mast cells, and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
- Immunogen:
- Mouse CD8b
- Isotyp:
- IgG2b, kappa
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Blue Ice
- Spezifität:
- The rat monoclonal antibody H35-17.2 recognizes an extracellular epitope of mouse CD8b, the 32-34 kDa beta chain of the CD8 coreceptor, expressed on cytotoxic T cells and thymocytes.
- Lagerbedingungen:
- 2-8[o]C Do not freeze.
- Hersteller:
- Exbio
- Typ:
- Antibody