Anti-LARGE1 Purified
Produktgrößen
0.025 mg
£138,00
11-702-0.025MG
0.1 mg
£235,00
11-702-0.1MG
Über dieses Produkt
- SKU:
- 11-702
- Anwendung:
- Flow Cytometry, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- LARGE-02
- Konzentration:
- 1 mg/ml
- Weitere Details:
- LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.
- Immunogen:
- Recombinant fragment of human LARGE1 (amino acids 35-142)
- Isotyp:
- IgG2b
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Spezifität:
- The mouse monoclonal antibody LARGE-02 recognizes human LARGE1, a glycosyltransferase expressed mainly in the Golgi apparatus. Crossreactivity with LARGE2 was not determined.
- Lagerbedingungen:
- 2-8[o]C Do not freeze.
- Hersteller:
- Exbio
- Typ:
- Antibody