Anti-Notch1 Purified
Produktgrößen
0.025 mg
£111,00
11-651-0.025MG
0.1 mg
£181,00
11-651-0.1MG
Über dieses Produkt
- SKU:
- 11-651
- Anwendung:
- Flow Cytometry, IHC-Frozen, Immunocytochemistry, Immunoprecipitation, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- mN1A
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Notch 1 is a 270-300 kDa transmembrane protein with multiple extracellular growth factor-like repeats, and with an intracellular domain consisting of multiple different domain types. It serves as a receptor for membrane ligands such as DLL1, Jagged 1 (CD339), and Jagged 2, and regulates cell fate decisions. Upon ligand binding the transmembrane form of Notch 1 is repeatedly cleaved to provide approximately 120 kDa Notch intracellular fragment (NICD), which translocates into the nucleus and acts as a part of transcriptional complexes that alter differentiation, proliferation, and apoptosis. The highest level of Notch 1 expression is in bone marrow progenitor cells, brain, lung and thymus.
- Immunogen:
- GST fusion protein containing cdc10-NCR region of mouse Notch1
- Isotyp:
- IgG1, kappa
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Spezifität:
- The mouse monoclonal antibody mN1A recognizes intracellular domain of Notch 1 protein, mainly its activated form. The unprocessed Notch 1 protein is recognized with lower affinity.
- Lagerbedingungen:
- 2-8[o]C Do not freeze.
- Hersteller:
- Exbio
- Typ:
- Antibody