Anti-AHNAK1 Purified
Produktgrößen
0.025 mg
£138,00
11-540-0.025MG
0.1 mg
£235,00
11-540-0.1MG
Über dieses Produkt
- SKU:
- 11-540
- Anwendung:
- IHC-Frozen, Immunocytochemistry, Immunoprecipitation, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- EM-09
- Konzentration:
- 1 mg/ml
- Weitere Details:
- AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increas of extracellular calcium level or upon proteinkinase C activation and regulates extracellular calcium influx mediated by L-type Ca2+ channels. AHNAK1 has been implicated in diverse signal transduction proceses affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies and is thus involved in organization of the plasma membrane architecture. In epithelial cells, AHNAK1 is localized in cytoplasm or is membrane-associated, but in cells of nonepithelial origin AHNAK1 is predominantly nuclear; it has a weak DNA-binding activity and associates with the DNA-ligase IV-XRCC4 complex.
- Immunogen:
- Bacterially expressed fragment of N-terminal domain of human AHNAK1.
- Isotyp:
- IgG1
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Spezifität:
- The mouse monoclonal antibody EM-09 reacts with AHNAK1, a 700 kDa multi-functional adaptor protein expressed mainly in epithelial cell, various types of muscle cells and immune cells.
- Lagerbedingungen:
- 2-8[o]C Do not freeze.
- Hersteller:
- Exbio
- Typ:
- Antibody