Anti-H-RAS Purified
Produktgrößen
0.025 mg
£121,00
11-527-0.025MG
0.1 mg
£202,00
11-527-0.1MG
Über dieses Produkt
- SKU:
- 11-527
- Anwendung:
- Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- H-RAS-03
- Konzentration:
- 1 mg/ml
- Weitere Details:
- H-Ras is one of three ubiquitously isoforms of Ras GTPase that operate at the intracellular leaflet of the plasma membrane to regulate multiple signal transduction pathways, such as mitogen-activated protein kinase (MAPK) cascade. H-Ras is anchored to the plasma membrane by farnesyl and two palmityl residues. GTP loading decreases H-Ras affinity for lipid rafts and allows the protein to target to nonraft microdomains, the primary sites of H-Ras signaling. Sos protein and other guanine nucleotide-exchange factors catalyze dissociation of GDP from Ras. Besides its roles in the plasma membrane, active H-Ras also diffuses through the cytoplasm on nanoparticles termed rasosomes, which is dependent on Ras palmitoylation.
- Immunogen:
- Peptide corresponding to amino acids DIHQYREQIKRVKDSDDC of human H-Ras protein
- Isotyp:
- IgG1
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Spezifität:
- The mouse monoclonal antibody H-RAS-03 reacts with human H-Ras, an ubiquitously expressed 21 kDa intracellular protein. Although reactivity with other species has not been determined, it is probable as the epitope is highly conserved among animals.
- Lagerbedingungen:
- 2-8[o]C Do not freeze.
- Hersteller:
- Exbio
- Typ:
- Antibody