Anti-Hu CD33 Purified
Produktgrößen
0.025 mg
£116,00
11-365-0.025MG
0.1 mg
£192,00
11-365-0.1MG
Über dieses Produkt
- SKU:
- 11-365
- Anwendung:
- Flow Cytometry
- CE/IVD:
- RUO
- translate.label.attr.clone:
- HIM3-4
- Konzentration:
- 1 mg/ml
- Weitere Details:
- CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia.
- Immunogen:
- NFMY-9s human cell line
- Isotyp:
- IgG1
- Reaktivitäten:
- Human, Non-human Primate
- Versandbedingungen:
- Blue Ice
- Spezifität:
- The antibody HIM3-4 reacts with an extracellular epitope of CD33, a 67 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells; it is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.
- Lagerbedingungen:
- 2-8[o]C Do not freeze.
- Hersteller:
- Exbio
- Typ:
- Antibody