Anti-Hu CD6 Purified
Produktgrößen
0.025 mg
£111,00
11-205-0.025MG
0.1 mg
£181,00
11-205-0.1MG
Über dieses Produkt
- SKU:
- 11-205
- Anwendung:
- Flow Cytometry, IHC-Paraffin, Immunoprecipitation, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- MEM-98
- Konzentration:
- 1 mg/ml
- Weitere Details:
- CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may exert some its functions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6 has antiapoptotic role in chronic lymphocytic leukemia B cells.
- Immunogen:
- Human CD6 antigen purified by immunoaffinity chromatography from HBP-ALL cells followed by preparative SDS-PAGE of non-boiled non-reduced sample (excised piece of gel corresponding to the 100 kDa zone).
- Isotyp:
- IgG1
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Spezifität:
- The antibody MEM-98 reacts with an extracellular epitope of CD6, a 100-130 kDa single chain transmembrane glycoprotein expressed on T and B lymphocytes subsets, thymocytes, and acute lymphocytic leukemia cells.
- Lagerbedingungen:
- 2-8[o]C Do not freeze.
- Hersteller:
- Exbio
- Typ:
- Antibody