Anti-Hu CD49d Purified
Produktgrößen
0.025 mg
£111,00
11-171-0.025MG
0.1 mg
£181,00
11-171-0.1MG
Über dieses Produkt
- SKU:
- 11-171
- Anwendung:
- Flow Cytometry, IHC-Frozen
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 9F10
- Konzentration:
- 1 mg/ml
- Weitere Details:
- CD49d / integrin alpha 4, unlike other alpha integrins, neither contains an I-domain, nor undergoes disulfide-linked cleavage. It associates with beta 7 chain to form alpha 4 / beta 7 integrin, and with beta 1 chain (CD29) to form VLA-4 integrin. These complexes are important for lymphocyte migration from circulation into tissue (binding VCAM-1) and homing of T cell subsets to Peyer's patches (binding MadCAM-1), but VLA-4 is also target for invasive bacteria which contain invasin. CD49d is essential for differentiation and migration of hematopoietic stem cells by their adhesion to bone marrow stromal cells, and provides a costimulatory signal to TCR-CD3 complex by inducing phosphorylation of some focal adhesion proteins.
- Isotyp:
- IgG1, kappa
- Reaktivitäten:
- Bovine, Canine, Feline, Horse, Human, Non-human Primate, Sheep
- Versandbedingungen:
- Blue Ice
- Spezifität:
- The mouse monoclonal antibody 9F10 recognizes an extracellular epitope of CD49d (alpha 4 integrin), a 145-180 kDa type I transmembrane glycoprotein expressed on B and T cells, monocytes, eosinophils, basophils, NK cells, and dendritic cells, but not platelets.
- Lagerbedingungen:
- 2-8[o]C Do not freeze.
- Hersteller:
- Exbio
- Typ:
- Antibody