Anti-Hu CD268 Purified
Produktgrößen
0.025 mg
£132,00
11-163-0.025MG
0.1 mg
£224,00
11-163-0.1MG
Über dieses Produkt
- SKU:
- 11-163
- Anwendung:
- Flow Cytometry, IHC-Frozen, IHC-Paraffin
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 11C1
- Konzentration:
- 1 mg/ml
- Weitere Details:
- CD268 / BAFF R is a TNFR family receptor that binds the B-cell-activating factor (CD257 / BAFF). Splice variants of CD268 have been observed both in man and mouse. A naturally occurring mutation of CD268 in A/WySnJ mice is associated with low number of mature B cells, but with normal B cell precursors. The role of BAFF in B-cell survival and activation make CD268 a potential diagnostic reagent. It may be involved in survival of B-cell malignancies. Experimental administration of a CD268-Fc fusion protein suppresses antibody responses. In T cells the CD268 costimulates their activation and proliferation. Defects in CD268 cause the common variable immunodeficiency 4 (CVID4).
- Immunogen:
- human CD268-transfected murine L1.2 cells
- Isotyp:
- IgG1, kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Spezifität:
- The mouse monoclonal antibody 11C1 recognizes an extracellular epitope of CD268 / BAFF R (B cell-activating factor receptor), a 19 kDa type III transmembrane protein expressed on resting B cells and CD4-positive T cells, but down regulated after activation.
- Lagerbedingungen:
- 2-8[o]C Do not freeze.
- Hersteller:
- Exbio
- Typ:
- Antibody