Anti-Hu CD314 Purified Azide Free
Produktgrößen
0.025 mg
£111,00
10-650-0.025MG
0.1 mg
£181,00
10-650-0.1MG
Über dieses Produkt
- SKU:
- 10-650
- Anwendung:
- Cell-based/Functional Assay, Flow Cytometry, IHC-Frozen, Immunoprecipitation
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 1D11
- Konzentration:
- 1 mg/ml
- Weitere Details:
- CD314, also known as NKG2D (natural killer receptor G2D) or KLRK1 (killer cell lectin-like receptor subfamily K, member 1), is a homodimeric C-type lectin-like activating receptor and costimulator with type II membrane orientation (C teminus extracellular). CD314 homodimers are associated with DAP10, a membrane adaptor protein that signals similar to CD28 by recruitment of phosphatidylinositol 3-kinase. Engagement of CD314 amplifies antigen-specific T cell responses in CD314-positive T cell populations. In NK cells, CD314 is a primary activating receptor. As CD314 ligands the MHC class-I chain-related proteins A and B (MICA, MICB) and UL16-binding proteins (ULBPs) have been identified.
- Immunogen:
- NKL cell line
- Isotyp:
- IgG1, kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Spezifität:
- The mouse monoclonal antibody 1D11 recognizes an extracellular epitope of CD314 / NKG2D, a 42 kDa C-type lectin-like activating receptor expressed by NK cells, gamma/delta T cells, and CD8+ T cells.
- Lagerbedingungen:
- 2-8[o]C Do not freeze.
- Hersteller:
- Exbio
- Typ:
- Antibody