KHDR3 rabbit pAb
Produktgrößen
50UL
£ POA
ES9757-50UL
100UL
£ POA
ES9757-100UL
Über dieses Produkt
- SKU:
- ES9757
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- domain:The proline-rich site binds the SH3 domain of the p85 subunit of PI3-kinase.;function:RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression.;induction:Induced in proteinuric diseases. Down-regulated in immortalized fibroblasts isolated after a proliferative crisis accompanied with massive cell death.;PTM:Phosphorylated on tyrosine residues. Isoform 1 C-terminal region is tyrosine-rich; but isoform 2 lacking this C-terminal region is also tyrosine-phosphorylated.;similarity:Belongs to the KHDRBS family.;similarity:Contains 1 KH domain.;subcellular location:Localized in a compartment adjacent to the nucleolus; but distinct from the peri-nucleolar one.;subunit:Self-associates to form homo-oligomers. Interacts with the splicing regulatory proteins SFRS9; SAFB and YTHDC1. Interacts also with HNRPL and SLM1/KHDRBS2 (By similarity). Interacts with KHDRBS1; RBMX; RBMY1A1 and with p85 subunit of PI3-kinase. Interacts also with SIAH1 which promotes targeting for degradation.;tissue specificity:Ubiquitous with higher expression in testis; skeletal muscle and brain. Expressed in the kidney only in podocytes; the glomerular epithelial cells of the kidney. Strongly expressed after meiosis.;
- Immunogen:
- Synthesized peptide derived from part region of human protein
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
