CBLB rabbit pAb
Produktgrößen
50UL
£ POA
ES9621-50UL
100UL
£ POA
ES9621-100UL
Über dieses Produkt
- SKU:
- ES9621
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- domain:The N-terminus is composed of the phosphotyrosine binding (PTB) domain; a short linker region and the RING-type zinc finger. The PTB domain; which is also called TKB (tyrosine kinase binding) domain; is composed of three different subdomains: a four-helix bundle (4H); a calcium-binding EF hand and a divergent SH2 domain.;domain:The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.;domain:The UBA domain interacts with poly-ubiquitinated proteins.;function:E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes; and transfers it to substrates; generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor); BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells; inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination; which impairs its recruitment to the TCR and subsequent activation. In activated T-cells; inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells; acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization.;miscellaneous:This protein has one functional calcium-binding site.;pathway:Protein modification; protein ubiquitination.;PTM:Auto-ubiquitinated upon EGF-mediated cell activation or upon T-cell costimulation by CD28; which promotes proteasomal degradation.;PTM:Phosphorylated on tyrosine residues upon TCR or BCR activation; and upon various types of cell stimulation.;sequence caution:Translated as Arg.;similarity:Contains 1 CBL N-terminal domain.;similarity:Contains 1 RING-type zinc finger.;similarity:Contains 1 SH2 domain.;similarity:Contains 1 UBA domain.;similarity:Contains 2 EF-hand-like domains.;subcellular location:Upon EGF stimulation; associates with endocytic vesicles.;subunit:Interacts with SH3 domain-containing proteins LCK; CRK and SORBS1. Interacts with LCP2 and ZAP70. May interact with CBL (By similarity). Interacts with SH3 domain-containing proteins VAV1; FYN; FGR; PLCG1; GRB2; CRKL; PIK3R1 and SH3KBP1/CIN85. Identified in heterotrimeric complexes with SH3KBP1/CIN85; CD2AP and ARHGEF7; where one CBLB peptide binds two copies of the other protein. Interacts with poly-ubiquitinated proteins. Dimerization is required for the binding of poly-ubiquitin; but not for the binding of mono-ubiquitin.;tissue specificity:Expressed in placenta; heart; lung; kidney; spleen; ovary and testis; as well as fetal brain and liver and hematopoietic cell lines; but not in adult brain; liver; pancreas; salivary gland; or skeletal muscle. Present in lymphocytes (at protein level).;
- Immunogen:
- Synthesized peptide derived from part region of human protein
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody