CDA7L rabbit pAb
Produktgrößen
50UL
£ POA
ES9119-50UL
100UL
£ POA
ES9119-100UL
Über dieses Produkt
- SKU:
- ES9119
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- function:Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2; but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.;induction:By MYC overexpression in a concentration dependent manner in neuroblastoma cell line.;miscellaneous:Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation.;subcellular location:Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.;subunit:Interacts with MYC and PSIP1.;tissue specificity:Ubiquitous. Overexpressed in medulloblastoma.;
- Immunogen:
- Synthesized peptide derived from human protein . at AA range: 140-220
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody