PTEN rabbit pAb
Produktgrößen
50UL
£ POA
ES8470-50UL
100UL
£ POA
ES8470-100UL
Über dieses Produkt
- SKU:
- ES8470
- Zusätzliche Namen:
- phosphatase and tensin homolog; phosphatase and tensin homolog pseudogene 1
- Anwendung:
- Immunofluorescence, Western Blot, Immunohistochemistry, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3;4;5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases; this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3;4;5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine; and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate ener
- Immunogen:
- Synthesized peptide derived from PTEN at AA range: 251-300
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
