TLE1/2/3/4 rabbit pAb
Produktgrößen
50UL
£ POA
ES8464-50UL
100UL
£ POA
ES8464-100UL
Über dieses Produkt
- SKU:
- ES8464
- Zusätzliche Namen:
- similar to transducin-like enhancer of split 1/2/3/4
- Anwendung:
- Western Blot, ELISA, Immunohistochemistry
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2; and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.;PTM:Phosphorylated; probably by CDC2. The degree of phosphorylation varies throughout the cell cycle; and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1.;similarity:Belongs to the WD repeat Groucho/TLE family.;similarity:Contains 6 WD repeats.;subcellular location:Nuclear and chromatin-associated; depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.;subunit:Homooligomer and heterooligomer with other family members. Binds LEF1; RUNX1; RUNX3; FOXA2; KDM6A; UTY; histone H3; HESX1; ESRRG and the NF-kappa-B subunit RELA. Interacts with HES1 (via WRPW motif).;tissue specificity:In all tissues examined; mostly in brain; liver and muscle.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from the C-terminal region of human TLE1/TLE2/TLE3/TLE4. AA range:721-770
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
